The contribution of increased thermogenesis to the effect of anorectic drugs on body composition in mice

摘要: The study investigated whether changes in body composition of normal and genetically obese C57BL/6J (ob/ob) mice caused by the anorectic drugs phentermine, diethylpropion, fenfluramine, mazindol are entirely due to reduced food intake. Mice were dosed daily (25 mg/kg po) for 28 days after which time carcass was determined. Compared controls fed at libitum, reductions intake 7%; 17%; 17%, whereas reduction lipid content 16%; mazindol, 18%; 8%; 10%. Since diet restriction 22% (in absence treatment with any drug) resulted a 12% below that ad these results suggest some loss phentermine possibly is increased energy expenditure. In support this conclusion, expenditure 35% compared untreated 6 h dosing but diethylpropion fenfluramine had little or no effect. Determination confirmed has metabolic antiobesity Fenfluramine an unexpected effect on mice.