Regulation of mammalian tooth cusp patterning by ectodin.
作者： Yoshiaki Kassai , Pauliina Munne , Yuhei Hotta , Enni Penttilä , Kathryn Kavanagh
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摘要: Mammalian tooth crowns have precise functional requirements but cannot be substantially remodeled after eruption. In developing teeth, epithelial signaling centers, the enamel knots, form at future cusp positions and are first signs of patterns that distinguish species. We report ectodin, a secreted bone morphogenetic protein (BMP) inhibitor, is expressed as "negative" image mouse knots. Furthermore, we show ectodin-deficient mice enlarged highly altered patterns, extra teeth. Unlike in normal excess BMP accelerates patterning propose ectodin critical for robust spatial delineation knots cusps.
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