Progress in the development of animal models of acute kidney injury and its impact on drug discovery

摘要: Introduction: Acute kidney injury (AKI) is a clinical syndrome characterized by the acute loss of function. AKI increasingly frequent and associated with impaired survival chronic disease progression. Experimental models have contributed to better understanding pathophysiological mechanisms but they not yet resulted in routine application novel therapeutic approaches. Areas covered: The authors present advances experimental over last decade. Furthermore, review their current expected impact on drug discovery. Expert opinion: New been developed rodents non-rodents. Non-rodents allow evaluation specific aspects both bigger animals simpler organisms such as drosophila zebrafish. rodent recently reproduced described entities, aristolochic warfarin nephropathies, also provided for old entities thrombotic...