13C NMR of intermediary metabolism: implications for systemic physiology.

摘要: ▪ Abstract The study of intermediary metabolism in biomolecules has been given new directions by recent experiments human muscle and brain 13C NMR. Labeled substrates, generally glucose, have enabled the fluxes to be determined vivo, whereas naturally abundant concentrations measured. In glycogen synthesis pathway measured flux control metabolic analysis data, which shows that this is mainly responsible for insulin-stimulated glucose disposal a deficiency transporter hyperglycemia non-insulin-dependent diabetics. From physiological point view most surprising result was heavily regulated allosteric enzyme, synthase, does not but needed maintain homeostasis during changes. This novel role phosphorylated enzyme proposed general phenomenon signaling pathways, w...