The Use of Nonsteroidal Anti-Inflammatory Drugs for Exercise-Induced Muscle Damage

摘要: Exercise-induced muscle damage (EIMD) is a common condition resulting from bout of vigorous exercise, particularly if the individual unaccustomed to performance given movement. Symptoms EIMD include delayed-onset soreness (DOMS) and loss physical function. Nonsteroidal anti-inflammatory drugs (NSAIDs) are routinely prescribed post-exercise alleviate these symptoms restore normal Of potential concern for those who use NSAIDs treat possibility that they may impair adaptive response exercise. Specifically, there emerging evidence action cyclo-oxygenase (COX) enzymes, COX-2 in particular, important even necessary achieve maximal skeletal hypertrophy functional overload. Given exert their actions by blocking COX thus suppressing prostaglandin production, theoretical rationale exists whereby have detrimental effects on regeneration super-compensation. Therefore, purpose this article extensively review literature evaluate growth development. Based current evidence, little reason believe occasional will negatively affect growth, although efficacy alleviating inflammatory remains questionable. Evidence hypertrophic chronic less clear. In untrained, it does not appear regular NSAID impede short term, at least one study indicates fact positive impact. reported impairment satellite cell activity, however, longer-term well be detrimental, possess greater potential.