Induction of Chirality in β-Turn Mimetic Polymer Conjugates via Postpolymerization “Click” Coupling
作者： Stefanie Deike , Wolfgang H. Binder
DOI: 10.1021/ACS.MACROMOL.7B00343
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摘要: Chiral and achiral β-turn mimetic polymer conjugates were synthesized, their chiroptical properties investigated. helical poly(n-hexyl isocyanate)s (PHICs) with alkyne functional end groups (4.0–5.4 kDa) synthesized via coordination polymerization using either a chiral or an alkyne-functional organotitanium catalyst. The obtained polymers coupled structure the copper-catalyzed azide/alkyne cycloaddition (CuAAC) reaction, in turn allowing to tune distance between PHIC-helix center from 7 14 A. successful linkage of was confirmed by size exclusion chromatography (SEC), high performance liquid (HPLC), 1H NMR spectroscopy, MALDI-ToF mass spectrometry, proving attachment one two PHIC-helices central β-turn. Circular dichroism (CD) spectra chirality induction bac...
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