摘要: Herpes simplex virus (HSV) types 1 (HSV-1) and 2 (HSV-2) are members of the family Herpesviridae. They belong to subfamily Alphaherpesvirinae genus Simplexvirus. The majority replicative intermediates long concatemers apparently generated through sequence replacement or insertion. rate neonatal herpes projected by this study was 33 100,000 live births, it highest in seronegative women. Using process, trigeminal sacral dorsal root ganglia were respectively identified as most common sites for latent HSV-1 HSV-2 infections, but latency can also be established central nervous system (CNS), primarily brain stem. current routine procedure increases sensitivity specificity antigen detection assays amplification short-term (16 24 h) growth tissue culture. original goals vaccination induce mucosal systemic immunity prevent infection transmission. Oncolytic viruses promising tools cancer gene therapy. Cancer therapy approach (known suicide) is based on ability HSV thymidine kinase (TK) preferentially activate ganciclovir, thereby killing tumor cells that contain TK well surrounding cells.
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