Role of miR-27 in controlling T cell immunity (IRM15P.605)

摘要: miR-23~27~24 clusters are highly enriched in regulatory cells while expressed at low levels conventional T cells. However, despite a selective expression pattern of cells, to date, studies this miRNA family have primarily focused on their role tumorigenesis. Here, we show play pivotal regulating cell immunity. Particularly, our results demonstrated that the majority cluster-dependent phenotypes could be attributed single member family, miR-27. Mice with cell-specific overexpression miR-27 spontaneously developed autoimmune phenotypes. On other hand, vitro polarization revealed exhibited impaired differentiation and effector function multiple helper lineages. Finally, mixed bone marrow chimeras further control different responses through either cell-intrinsic or -extrinsic manner. Collectively, Our identify new "immune regulatory" can multi-faceted roles