GC-MS and GC-IR analysis of regioisomeric cannabinoids related to 1-(5-fluoropentyl)-3-(1-naphthoyl)-indole

摘要: Abstract The compounds in this study are the regioisomeric 2-, 3-, 4-, 5-, 6- and 7-(1-naphthoyl) substituted 1-(5-fluoropentyl)-indoles 3-(1-naphthoyl) isomer series is also known as AM-2201. These structurally similar to JWH-018 except for additional fluorine at terminal end of n-pentyl side-chain. six have identical elemental composition (C24H22FNO) differ position attachment 1-napthoyl group on indole ring. electron ionization mass spectra showed major fragment ions with a molecular radical cation significant abundance m/z 359. 127 155 naphthyl naphthoyl cations. There prominent ion 342 [M−17]+ EI-MS 1-(5-fluoropentyl)-3-, 5- 6-(1-naphthoyl)-indoles due loss hydroxyl most (AM-2201). were separated using gas chromatography capillary column containing trifluoropropylmethyl polysiloxane (Rtx-200) stationary phase. elution order appears be related steric crowding ring substituents. 7- 2-(1-naphthoyl) isomers eluted first possibility maximum interactions between naphthyol alkyl side-chains. vapor phase infrared differentiate among these based 1-naphthoyl compared non-fluorinated analogues, its equivalents.