Expression and significance of tumor-related genes in HCC
作者： Zi-Li Lü
关键词:
摘要: AIM: To investigate the expression and clinical significance of DEK, cyclin D1, insulin-like growth factor II (IGF-II), glypican 3 (GPC3), ribosomal phosphoprotein 0 (rpP0) mRNA in hepatocellular carcinoma (HCC) its paraneoplastic tissues. METHODS: The mRNAs IGF-II, GPC3 rpP0 was detected HCC tissues by multiplex RT-PCR. RESULTS: By simplex RT-PCR, overexpression GPC3, 78.1%, 87.5%, 75.0%, 81.3% 15.6%, 40.6%, 37.5%, 21.9%, 31.3% respectively (P 0.05). However, all these five were found 68.8% samples, but only 9.4% genes HCCs with α-feto protein (AFP) negative positive 90.0%, 80.0%, 90.0% 72.7%, 86.3%, 77.3%, 90.9%, 68.2% > 0.05). CONCLUSION: is much higher than tissues. Multiplex RT-PCR assay an effective, sensitive, accurate, cost-effective diagnostic method HCC.
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