Severity and duration of depression, not personality factors, predict short term outcome in the treatment of major depression.

摘要: Abstract Background Prediction of treatment outcome has important clinical consequences. Personality factors have rarely been tested as predictors acute outcome. Personality, demographic and illness-related characteristics were assessed at baseline for prediction in depressed out-patients. Methods One hundred ninety-three patients with major depressive disorder (MDD) enrolled a 12 to 16 week trial. The consisted nefazodone, nefazodone combination interpersonal psychotherapy (IPT), IPT placebo alone. Demographic illness related variables collected baseline. was using the NEO-FFI. This instrument measures five dimensions personality. A hierarchical logistic regression carried out test significant remittance. Further multiple analysis used investigate predictive changes on Hamilton Depression Rating Scale dependent variable. Results Univariate showed relationship severity, duration index episode, use medical services (UMS). None personality Regression analyses that these disease each uniquely predicted outcome, but did not significantly contribute model. Limitations study secondary tertiary care centers may be generalizable other populations. self-report prone bias. Conclusions Severity lesser extent, UMS, factors, predict short term MDD.