Selection against BALB/c strain cells in mouse chimaeras.
作者： Pin-Chi Tang , Gillian E. MacKay , Jean H. Flockhart , Margaret A. Keighren , Anna Kopakaki
DOI: 10.1242/BIO.030189
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摘要: ABSTRACT It has been shown previously that BALB/c strain embryos tend to contribute poorly mouse aggregation chimaeras. In the present study we showed cells were not preferentially allocated any extraembryonic lineages of chimaeras, but their contribution decreased during early postimplantation period and they significantly depleted by E8.5. The development preimplantation lagged behind from some other strains made chimaeras correlated with developmental stage at E2.5. This relationship suggests poor is least partly a consequence generalised selection related slow or delayed development. suitability for maximising ES cell also discussed.
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