Some Ultrastructural Aspects of Experimental and Human Carcinoma of the Bladder

摘要: Summary Transmission electron microscopic studies of events in a model experimental bladder carcinoma the rat were reported and compared with normal structure. Epithelial during carcinogenesis briefly discussed terms sequential changes cell-to-cell relationships, asymmetric unit membrane, Golgi apparatus, keratinization. Nonepithelial but related pertaining to lamina densa basement membrane subepithelial capillary vessels also described illustrated. It is suggested that many recorded may reflect rapid epithelial growth turnover rather than specific morphological expressions carcinogenesis. On other hand, some such as very early injury apparatus occurrence microvilli on surfaces all cells cannot be so explained represent more response carcinogen. The significance nonepithelial multiplication thickening proliferation abnormal capillaries surrounded by their own multilayered was discussed. squamous metaplasia considered possible factor formation invasive carcinoma. most papillary tumors cancer are perhaps not except time space. Ultrastructural observed human hyperplastic urothelium summarized, points similarity system noted. these observations light Cairns9 theory Full elucidation causing effecting malignant transformation clearly requires additional work.