Pediatric transfusion therapy: Practical considerations

摘要: Over the past decade, safety of blood has increased tremendously because better donor screening as well testing units for transmissible diseases. Component therapy allowed more effective and economic use blood. Whole is rarely used; instead, packed red cells, platelets, fresh frozen plasma (FFP) are most common components used. These products further refined using irradiation microaggregate filters in case FFP, viral inactivation. Irradiation prevents transfusion-associated graft versus host disease, whereas remove leukocytes, decreasing rates alloimmunization, febrile nonhemolytic (FNH) reactions, cytomegalovirus (CMV) transmission. Autologous donation older children probably provides safest far diseases concerned. More families request a directed solicit physician help deciding making arrangements autologous and/or donations. Transfusions often challenging require knowledge physiologic changes hemoglobin volumes during different ages. The unique needs neonates, immunocompromised patients, patients with congenital hemolytic anemia (sickle cell, thalassemia) mandate that pediatrician have an appropriate transfusion choice product indications transfusion.