DNA as Immunogen for the Induction of Immune and Autoimmune Antibody in Mice

摘要: Mice from strains genetically predisposed to the development of systemic autoimmune diseases have been an invaluable experimental resource for research efforts understand basis human disease lupus erythematosus (SLE) (1). There are clear differences in clinical presentation mice compared patients (2). Nevertheless, much useful information has gained by studies mice, particularly those MRL lpr/lpr, NZB, NZW, and (NZB x NZW)F1 strains. Studies these mouse informative helping us antibody responses DNA. Lupus humans as defined American Rheumatism Association is a more heterogeneous than that lupus-prone (3,4). The presence serum nuclear antigens, particular DNA, only one diagnostic criteria. In this regard, may be representative form associated with autoantibodies which most important nephritis antibodies objective chapter review results derived anti-DNA mice. For part, will concentrate on obtained Although underlying genetic bases phenotype different other strains, such BXSB, motheaten (1), characteristics DNA similar.