Carrying the past to the future: Distinct brain networks underlie individual differences in human spatial working memory capacity.

摘要: Abstract Spatial working memory (SWM) relies on the interplay of anatomically separated and interconnected large-scale brain networks. EEG studies often observe load-associated sustained negative activity during SWM retention. Yet, whether how such in retention relates to network-specific functional activation/deactivation individual differences capacity remain be elucidated. To cover these gaps, we recorded concurrent EEG-fMRI data 70 healthy young adults Sternberg delayed-match-to-sample task with three load levels. a subset participants (N = 28) that performed properly had artefact-free fMRI data, employed novel temporo-spatial principal component analysis derive load-dependent slow wave (NSW) from retention-related event-related potentials. The associations between NSW responses were divergent higher (N = 14) lower groups. Specifically, larger load-related increase amplitude was associated greater for group but group. Furthermore, group, related activation bilateral parietal areas fronto-parietal network (FPN) deactivation medial frontal gyrus posterior mid-cingulate cortex default mode (DMN) In contrast, did not show similar pattern. Instead, linked right middle temporal gyrus. Our findings shed light possible differential EEG-informed neural mechanism maintenance underlying capacity.