Role of colonic microbiota in colorectal carcinogenesis: a systematic review

摘要: Background and aim: The human colonic mucosa is populated by a wide range of microorganisms, usually in symbiotic relation with the host. Sometimes this balance lost state dysbiosis arises, exposing colon to different metabolic inflammatory stimuli (according microbiota’s changing profile). Recent findings lead hypothesize that unbalance may create subclinical pro-inflammatory increases DNA mutations and, therefore, colorectal carcinogenesis. In article we aim systematically review scientific evidence regarding microbiota its role Methods: Systematic PubMed searching results for original articles studying cancer until November 2014. Results: Thirty-one studied carcinoma including both animal studies. Different heterogeneous methods were used bacteria considered. Nevertheless, some are consistently augmented (such as Fusobacteria, Alistipes, Porphyromonadaceae, Coriobacteridae, Staphylococcaceae, Akkermansia spp. Methanobacteriales), while other constantly diminished Bifidobacterium, Lactobacillus, Ruminococcus, Faecalibacterium spp., Roseburia, Treponema). Moreover, metabolites amino acids increased butyrate decreased throughout Conclusion: Conclusive shows carcinogenesis associated microbial dysbiosis. This information be new prophylactic, diagnostic therapeutic strategies cancer.