Comparison of Clinical Outcomes Between Second-and First-Generation Drug-Eluting Stents in Patients With Chronic Total Occlusion Lesion: A Meta-Analysis.

摘要: Background and Objectives: The second-generation drug-eluting stents have been used to treat chronic total occlusion lesion. However, there is limited evidence of the clinical outcomes that whether superior first-generation ones in patients with lesion undergoing percutaneous coronary intervention. study aimed compare differences between two generations those by a meta-analysis. Methods: PubMed, Embase, Cochrane library Web science databases were systemically searched before March, 2021. Randomized controlled trials observational studies included major adverse cardiac events (MACE), target vessel revascularization, myocardial infarction, all-cause death. Fixed effects models calculate odds ratio (OR) 95% confidence interval (CI) each outcome. Sensitivity analysis was performed detect potential sources heterogeneity. Subgroup analyses assess differential effects. Results: meta-analysis eight involving 4,583 Pooled showed incidence MACE (OR = 0.68, 95%CI 0.54-0.85, P 0.0008), revascularization 0.70, 0.54-0.91, 0.007), infarction 0.58, 0.37-0.93, 0.02) lower compared ones. not difference deaths 0.67, 0.45-1.01, 0.05). Conclusions: are associated MACE, results this can provide reference for selection Further randomized needed verify (Registered PROSPERO, CRD42020158406).