Encapsulating Ionic Liquid and Fe3O4 Nanoparticles in Gelatin Microcapsules as Microwave Susceptible Agent for MR Imaging-guided Tumor Thermotherapy
作者： Qijun Du , Tengchuang Ma , Changhui Fu , Tianlong Liu , Zhongbing Huang
关键词:
摘要: The combination of therapies and monitoring the treatment process has become a new concept in cancer therapy. Herein, gelatin-based microcapsules have been first reported to be used as microwave (MW) susceptible agent magnetic resonance (MR) imaging contrast for MW thermotherapy. Using simple coacervation methods, ionic liquid (IL) Fe3O4 nanoparticles (NPs) were wrapped microcapsules, these showed good heating efficacy vitro under irradiation. results cell tests indicated that gelatin/IL@Fe3O4 possessed excellent compatibility physiological environments, they could effectively kill cells with exposure MW. ICR mice bearing H22 tumors treated obtained an outstanding thermotherapy 100% tumor elimination ultralow density irradiation (1.8 W/cm2, 450 MHz). In addition, applicability efficient MR ...
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