The serine/threonine phosphatases of apicomplexan parasites.

摘要: The balance between phosphorylation and de-phosphorylation, which is delicately regulated by protein kinases phosphatases, critical for nearly all biological processes. Apicomplexa are a large phylum contains various parasitic protists, including human pathogens, such as Plasmodium, Toxoplasma, Cryptosporidium Babesia species. diverse life cycles of these parasites highly complex and, not surprisingly, many their key steps exquisitely phosphorylation. Interestingly, the well substrates involved in events unique to therefore constitutes viable target antiparasitic intervention. Most progress on this realm has come from studies Toxoplasma Plasmodium respective kinomes phosphoproteomes. Nonetheless, given likely importance, phosphatases have recently become focus research within apicomplexan parasites. In review, we concentrate serine/threonine parasites, with comprehensively identifying naming available genomes, summarizing functional analyses recent years.