Construction and validation of a novel prognostic nomogram for patients with sarcomatoid renal cell carcinoma: a SEER-based study

摘要: The only one established prognostic nomogram for patients with sarcomatoid renal cell carcinoma (sRCC) was based on a small sample-sized study without external validation, and can be applied to western sRCC has not yet been developed. Therefore, our aimed construct validate an effective predict overall survival (OS) these patients. independent predictors OS were identified the constructed basis of retrospective training cohort consisted 428 non-Hispanic white registered in Surveillance, Epidemiology End Results (SEER) database from January 2010 December 2015. Then, discriminative performance assessed by concordance index (C-index). calibrations also performed comparing nomogram-predicted probability observed rate. Furthermore, externally validated using two cohorts 71 black 82 Hispanic patients, respectively. Age at diagnosis, T stage, N bone metastases, liver lung metastases nephrectomy as OS. In validation cohorts, C-indexes 0.737, 0.801 0.764, Besides, excellent agreements between prediction actual observation achieved all cohorts. current sRCC, which used perform accurate predictions 0.5-, 1-, 2-year possibilities