The morpheein model of allostery: evaluating proteins as potential morpheeins.

摘要: An equilibrium mixture of alternate quaternary structure assemblies can form a basis for allostery. The morpheein model allostery is concerted dissociative that describes an whose architectures are dictated by conformations in the dissociated state. Kinetic and biophysical anomalies suggest applies given protein interest briefly described. Two methods presented evaluating proteins as potential morpheeins. One subunit interchange method uses chromatography, dialysis, mass spectroscopy to monitor changes multimer composition. other two-dimensional native gel electrophoresis ligand-induced multimeric assemblies.