Androgens, lipogenesis and prostate cancer

摘要: Both experimental and epidemiological data indicate that androgens are among the main factors controlling development, maintenance progression of prostate cancer. Identifying genes regulated by represents a major step towards elucidation mechanisms underlying impact on cancer cell biology is an attractive approach to find novel targets for therapy. Among have been identified thus far, several encode lipogenic enzymes. Studies aimed at androgen regulation revealed coordinately stimulate expression these through interference with molecular mechanism activation sterol regulatory element-binding proteins (SREBPs), transcription governing cellular lipid homeostasis. The resulting increase in lipogenesis serves synthesis key membrane components (phospholipids, cholesterol) hallmark cells. Pharmacologic inhibition or RNA-interference-mediated down-regulation induces apoptosis lines reduces tumor growth xenograft models. While increased already found earliest stages development (PIN) initially androgen-responsive it persists re-emerges androgen-independent cancer, indicating fundamental aspect potential target chemoprevention antineoplastic therapy advanced