Alkynylation of cyclopropyl trifluoromethyl ketone catalyzed by CuF2·2H2O/4,7-diphenyl-1,10-phenanthroline
作者： Xiao-Dong Liu , Hai-Yan Ma , Chun-Hui Xing , Long Lu
DOI: 10.1016/J.TETLET.2017.03.010
关键词:
摘要: Abstract CuF 2 ·2H O/4,7-diphenyl-1,10-phenanthroline was found to be a highly efficient catalyst for the nucleophilic alkynylation of cyclopropyl trifluoromethyl ketone. The corresponding trifluoromethyl-substituted tertiary propargyl alcohols were synthesized in moderate excellent yields under mild conditions. system could also applied aromatic ketone as well trifluoropyruvate.
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