Tuning of feedforward control enables stable muscle force-length dynamics after loss of autogenic proprioceptive feedback.

摘要: Animals must integrate feedforward, feedback and intrinsic mechanical control mechanisms to maintain stable locomotion. Recent studies of guinea fowl (Numida meleagris) revealed that the distal leg muscles rapidly modulate force work output minimize perturbations in uneven terrain. Here we probe role reflexes rapid perturbation responses muscle by studying effects proprioceptive loss. We induced bilateral loss autogenic proprioception lateral gastrocnemius (LG) using self-reinnervation. compared vivo dynamics ankle kinematics birds with reinnervated intact LG. Reinnervated LG exhibit similar steady state function modulation response obstacle encounters. exhibits 23ms earlier steady-state activation, consistent feedforward tuning activation phase compensate for lost proprioception. Modulation activity duration is impaired rLG, confirming reflex regulating muscle.