Pharmacology of Cytostatic Drugs

摘要: When planning to give a cytostatic drug patient, the broad assumptions are made that free active or drugs can be delivered target site, it tumour-cell membrane, nuclear DNA nucleotides; duration of exposure then regulated; and eventually cleared from site by metabolism excretion. The application such theory human situation is impossible without knowledge drug’s pharmacology. It now possible test sensitivity patient’s tumour variety in different doses schedules. To achieve same concentration child, however, absorption drug, distribution, liver clearance bile urine must considered. Drug disposition studies therefore become relevant optimizing treatment.