Method for the assessment of pharmacogenetic response to treatment with lithium salts in bipolar disorder
作者： M Del Zompo , Alessio Squassina , G. P. Patrinos
DOI:
关键词:
摘要: Bipolar disorder is a mental disease which characterized by major episodes alternating between maniacal and depressive states, affect 1 to 5% of the population, prevalently treated with lithium salts. Not all patients, however respond this treatment. The described invention relates method for pharmacogenetic assessment response treatment salts in patients bipolar based on detection polymorphism located intron amiloride-sensitive cation channel 1, neuronal gene (ACCN1 ).
lens.org 参考文章(30)
Konstantinos N. Fountoulakis, The Contemporary Face of Bipolar Illness: Complex Diagnostic and Therapeutic Challenges Cns Spectrums. ,vol. 13, pp. 763- 779 ,(2008) , 10.1017/S1092852900013894
John R. Kelsoe, Method to predict the response to lithium treatment ,(2006)
Graphic representation of the life course of illness in patients with affective disorder. American Journal of Psychiatry. ,vol. 145, pp. 844- 848 ,(1988) , 10.1176/AJP.145.7.844
John A. Wemmie, Margaret P. Price, Michael J. Welsh, Acid-sensing ion channels: advances, questions and therapeutic opportunities Trends in Neurosciences. ,vol. 29, pp. 578- 586 ,(2006) , 10.1016/J.TINS.2006.06.014
Jean Endicott, A Diagnostic Interview Archives of General Psychiatry. ,vol. 35, pp. 837- 844 ,(1978) , 10.1001/ARCHPSYC.1978.01770310043002
J Liu, S H Juo, A Dewan, A Grunn, X Tong, M Brito, N Park, J E Loth, K Kanyas, B Lerer, J Endicott, G Penchaszadeh, J A Knowles, J Ott, T C Gilliam, M Baron, Evidence for a putative bipolar disorder locus on 2p13-16 and other potential loci on 4q31, 7q34, 8q13, 9q31, 10q21-24, 13q32, 14q21 and 17q11-12. Molecular Psychiatry. ,vol. 8, pp. 333- 342 ,(2003) , 10.1038/SJ.MP.4001254
Janusz K. Rybakowski, Maria Skibinska, Aleksandra Suwalska, Anna Leszczynska-Rodziewicz, Leszek Kaczmarek, Joanna Hauser, Functional polymorphism of matrix metalloproteinase-9 (MMP-9) gene and response to lithium prophylaxis in bipolar patients. Human Psychopharmacology-clinical and Experimental. ,vol. 26, pp. 168- 171 ,(2011) , 10.1002/HUP.1182
Ross J. Baldessarini, Leonardo Tondo, Does Lithium Treatment Still Work? Archives of General Psychiatry. ,vol. 57, pp. 187- 190 ,(2000) , 10.1001/ARCHPSYC.57.2.187
M. W. Coryell, A. M. Wunsch, J. M. Haenfler, J. E. Allen, M. Schnizler, A. E. Ziemann, M. N. Cook, J. P. Dunning, M. P. Price, J. D. Rainier, Z. Liu, A. R. Light, D. R. Langbehn, J. A. Wemmie, Acid-Sensing Ion Channel-1a in the Amygdala, a Novel Therapeutic Target in Depression-Related Behavior The Journal of Neuroscience. ,vol. 29, pp. 5381- 5388 ,(2009) , 10.1523/JNEUROSCI.0360-09.2009
Mirko Manchia, Alessio Squassina, Donatella Congiu, Caterina Chillotti, Raffaella Ardau, Giovanni Severino, Maria Del Zompo, Interacting genes in lithium prophylaxis: Preliminary results of an exploratory analysis on the role of DGKH and NR1D1 gene polymorphisms in 199 Sardinian bipolar patients Neuroscience Letters. ,vol. 467, pp. 67- 71 ,(2009) , 10.1016/J.NEULET.2009.10.003