Inactivation of hepatitis B virus by intermediate-to-high-level disinfectant chemicals

摘要: In five separate tests, hepatitis B virus in dried human plasma was exposed for 10 min at 20 degrees C to disinfectant chemicals having activity levels ranging from intermediate (e.g., 70% isopropyl alcohol) high 2% aqueous glutaraldehyde pH 8.6). Five chimpanzees (one animal per chemical) received treated material intravenously, and none showed signs of infection after post-inoculation periods 9 months. Two animals were rechallenged with inoculum the same manner, except that saline used instead a chemical; both infected within 4 weeks. Our results not as resistant once thought suggested similar (intermediate high) might possibly be on contamination margin safety.