Pharmacokinetics of caffeine in lactating dairy cows.

摘要: Because caffeine is metabolized by the hepatic P-450 cytochrome oxidase system, clearance of an excellent quantitative test function in human beings. It currently used much same way that creatinine to assess renal function. Caffeine was measured lactating dairy cows initially determine suitability as indicator cattle. Pharmacokinetic variables were studied 6 adult after i.v. administration a single dose sodium benzoate (2 mg caffeine/kg body weight). concentration analyzed use automated enzyme immunoassay. The lower limit detection assay for serum 0.079 micrograms/ml. Serum concentration-time curves best fit open two-compartment pharmacokinetic model. Harmonic mean elimination half-life 3.8 (range, 2.6 6.9) hours, and total 0.118 0.090 0.197) L/kg/h. Milk similar 1.5 24 hours administration. Adverse effects not observed given caffeine.