MicroRNAs modulate the angiogenic properties of HUVECs.

摘要: MicroRNAs (miRNAs) have recently come into focus as key posttranscriptional modulators of gene expression. In this work, we addressed whether in vitro angiogenesis is an miRNA-regulated process. We performed large-scale analysis miRNA expression human umbilical vein endothelial cells (HUVECs) and found that 15 highly expressed miRNAs the receptors angiogenic factors putative targets. particular, demonstrated miR-221 miR-222 affect c-Kit and, a consequence, properties its ligand stem cell factor. Interaction between likely to be part complex circuit controls ability form new capillaries.