Thermodynamics of the Interaction of Proteins with Lipid Membranes

摘要: Peripheral proteins associated at the lipid surface are one of major components biological membranes. They may function in situ as electron carriers (e.g., cytochrome c), enzymes protein kinase C), signal transduction G-proteins), or primarily structural elements spectrin and myelin basic protein). The density membrane can be relatively high, peripheral also interact with exposed portions integral embedded within redox respiratory chain, receptors such those to which G-proteins coupled). association is most frequently electrostatic origin but include adsorption hydrophobic components. interactions isolated bi-layer membranes, therefore, direct relevance structure determination binding isotherms has proved particularly useful study interactions. Analysis latter constitutes first an important part this chapter that directly relevant thermodynamics binding.