Concomitant infection with Leishmania donovani and Plasmodium berghei alters clinical and immune responses in BALB/c mice

摘要: Malaria and visceral leishmaniasis coexist in the same geographical regions. However, dual co-infection with parasites causing these diseases their impact on public health is poorly documented. Interactions between may play a role disease outcome. The present study set out to evaluate clinical immunological parameters following Leishmania donovani Plasmodium berghei BALB/c mice. Mice were divided into four groups; L. donovani- only, P. , berghei- only naive. Body weight, parasite burden, total IgG, IFN-{gamma} IL-4 responses determined. To determine survival rate, mice used from each group. Tissues for histological analysis taken spleen, liver brain. Results indicated significant differences body weight (P<0.0001), load (P< 0.0001 ), IgG 0.0001), parasitemia (P= 0.0222), 0.002), (P<0.0001) dual-infected There was no correlation single or infections, while there positive relationship of infection group only. had highest mortality rate compared - infected groups. Histological analyses showed enlarged red white pulps pathological changes brain tissues which less pronounced co-infected We conclude that reduces severity seem correlate variation serum cytokines (IFN-{gamma} IL-4). Therefore, recommends importance inclusion early screening malaria Visceral Leishmaniasis patients regions where co- endemic.