2-Methylpyridinium/pyridinium 5-(2,4-dinitrophenyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-olates as potent anticonvulsant agents—synthesis and crystal structure

摘要: The molecular salt, 2-methylpyridinium 5-(2,4-dinitrophenyl)-2,6-dioxo-1,2,3,6-tetrahydropy-rimidin-4-olate) (I), is prepared from the ethanolic solution of 1-chloro-2,4-dinitrobenzene, pyrimidine-2,4,6-(1H,3H,5H)-trione (barbituric acid) and 2-methylpyridine at room temperature, pyridinium 5-(2,4-dinitrophenyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-olate (II), same reactants, by dissolving them in hot DMSO ethanol mixture 70°C. structures I II are characterized visible, IR, 1H-NMR, 13C-NMR elemental analysis confirmed single crystal X-ray analysis. Both salts crystallize triclinic system with sp. gr. \(P\bar 1\). They possess noticeable anticonvulsant activity even low concentration (25 mg/kg). Acute toxicity studies these complexes indicate that LD50 values greater than 1500 mg/kg tested animals do not show any behavioural changes.