Fibronectin Matrix Assembly after Spinal Cord Injury
作者： Yunjiao Zhu , Cynthia Soderblom , Michelle Trojanowsky , Do-Hun Lee , Jae K. Lee
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摘要: Abstract After spinal cord injury (SCI), a fibrotic scar forms at the site that is best characterized by accumulation of perivascular fibroblasts and deposition extracellular matrix protein fibronectin. While fibronectin growth-permissive substrate for axons, inhibitory to axon regeneration. The mechanism behind how contributes environment assembled in unknown. By deleting myeloid cells, we demonstrate are most likely major source scar. In addition, initially present soluble form into 7 d post-SCI. Assembly may be mediated canonical receptor, integrin α5β1, which primarily expressed activated macrophages/microglia Despite pronounced cavitation after rat SCI, sc...
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