Analogues of oxy-heme Aβ: reactive intermediates relevant to Alzheimer's disease
作者： Manas Seal , Soumya Mukherjee , Debajyoti Pramanik , Kaustuv Mittra , Abhishek Dey
DOI: 10.1039/C2CC37626A
关键词:
摘要: Redox active metals (Fe and Cu) cofactors (heme) bind to Aβ peptides react with O2 in their reduced state leading oxidative stress the brain. In this study we cryogenically trap characterize a Fe–O2 intermediate, using resonance Raman spectroscopy, involved reactive oxygen species formation by peptides. This is first reaction intermediate relevant Alzheimer's disease be reported.
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