Associations between calcium and vitamin D supplement use as well as their serum concentrations and subclinical cardiovascular disease phenotypes

摘要: Abstract Background Supplementation of calcium (Ca) and vitamin D for the prevention osteoporosis is frequently found in Western countries. Recent re-analyses clinical trials observed a higher risk myocardial infarction stroke subjects taking Ca (+vitamin D) supplements, although underlying mechanisms are not clear. Objective Thus, we analyzed associations between supplementation as well serum concentrations 25-hydroxyvitamin (25(OH)D) subclinical cardiovascular disease (CVD) phenotypes, namely intima-media thickness, ankle-brachial-index (ABI), intermittent claudication, atrial fibrillation (AF). Design Data 1601 participants aged 50–81 years population-based cross-sectional Cooperative Health Research Region Augsburg (KORA) F4 study Germany were analyzed. Logistic linear regression models used to estimate odds ratios (OR) (95% confidence intervals (CI)) β-estimates (p-values), respectively. Results Regular showed significant positive association with presence AF after multivariable adjustment (OR = 3.89; 95% CI 1.28–11.81). Higher 25(OH)D independently associated lower prevalence asymptomatic peripheral arterial assessed by ABI measurements (β = 0.007; p = 0.01). No other or CVD phenotypes identified. Conclusions Although based on few cases finding supplement users hints at one possible mechanism that may contribute an increased stroke. The supports results from studies.