Protein expression profile and microRNA expression signature in estrogen receptor-positive and -negative breast cancers: report of two cases.
作者： Rie Nakagawa , Yoshitomo Koshida , Eisuke Fukuma , Yuko Tsunoda , Akiko Sasaki
DOI: 10.2147/BCTT.S181652
关键词:
摘要: Background Identification of the proteins that are associated with estrogen receptor (ER) status is a first step in selecting drugs against hormone-dependent breast cancer. Recently, ER were reported using liquid chromatography and tandem mass spectrometry, microRNA (miRNA) profiling cancer subtype was demonstrated real-time-PCR. Methods We present herein two cases differential protein expression miRNA ER-positive -negative Results Proteins fatty acid metabolism uniquely detected The level miR-181a higher than ER-negative cancer, while miR-27a, miR-107, miR-195 lower compared Conclusion These suggest synthase (FAS) FAS-related miRNAs important
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