Diabetes, cancer, and metformin: connections of metabolism and cell proliferation

作者: Emily Jane Gallagher , Derek LeRoith

DOI: 10.1111/J.1749-6632.2011.06285.X

关键词:

摘要: … by increasing hepatic growth hormone receptor (GHR) … Caloric restriction can potentially reduce tumor growth by multiple mechanisms. Insulin sensitivity increases with calorie restriction…

参考文章(136)
Todd MacKenzie, Michael S. Zens, Assiamira Ferrara, Alan Schned, Margaret R. Karagas, Diabetes and risk of bladder cancer: evidence from a case-control study in New England. Cancer. ,vol. 117, pp. 1552- 1556 ,(2011) , 10.1002/CNCR.25641
Michal Armoni, Michael J. Quon, Gila Maor, Smadar Avigad, David N. Shapiro, Chava Harel, Diana Esposito, Yaacov Goshen, Isaac Yaniv, Eddy Karnieli, PAX3/Forkhead Homolog in Rhabdomyosarcoma Oncoprotein Activates Glucose Transporter 4 Gene Expression in Vivo and in Vitro The Journal of Clinical Endocrinology and Metabolism. ,vol. 87, pp. 5312- 5324 ,(2002) , 10.1210/JC.2002-020318
Josie M M Evans, Louise A Donnelly, Alistair M Emslie-Smith, Dario R Alessi, Andrew D Morris, Metformin and reduced risk of cancer in diabetic patients BMJ. ,vol. 330, pp. 1304- 1305 ,(2005) , 10.1136/BMJ.38415.708634.F7
Keiko Kawauchi, Keigo Araki, Kei Tobiume, Nobuyuki Tanaka, p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation. Nature Cell Biology. ,vol. 10, pp. 611- 618 ,(2008) , 10.1038/NCB1724
Hashem B. El–Serag, Howard Hampel, Fariba Javadi, The Association Between Diabetes and Hepatocellular Carcinoma: A Systematic Review of Epidemiologic Evidence Clinical Gastroenterology and Hepatology. ,vol. 4, pp. 369- 380 ,(2006) , 10.1016/J.CGH.2005.12.007
Z Fu, D J Tindall, FOXOs, cancer and regulation of apoptosis Oncogene. ,vol. 27, pp. 2312- 2319 ,(2008) , 10.1038/ONC.2008.24
Fabiana Schwartzenberg-Bar-Yoseph, Michal Armoni, Eddy Karnieli, None, The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression. Cancer Research. ,vol. 64, pp. 2627- 2633 ,(2004) , 10.1158/0008-5472.CAN-03-0846
Jacqueline M. Major, Gail A. Laughlin, Donna Kritz-Silverstein, Deborah L. Wingard, Elizabeth Barrett-Connor, Insulin-Like Growth Factor-I and Cancer Mortality in Older Men The Journal of Clinical Endocrinology and Metabolism. ,vol. 95, pp. 1054- 1059 ,(2010) , 10.1210/JC.2009-1378
Mohamad-Yehia El-Mir, Véronique Nogueira, Eric Fontaine, Nicole Avéret, Michel Rigoulet, Xavier Leverve, Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. Journal of Biological Chemistry. ,vol. 275, pp. 223- 228 ,(2000) , 10.1074/JBC.275.1.223