Tissue functions mediated by β3-adrenoceptors—findings and challenges

摘要: As β3-adrenoceptor agonists metamorphose from experimental tools into therapeutic drugs, it is vital to obtain a comprehensive picture of the cell and tissue functions mediated by this receptor subtype in humans. Human tissues with proven and/or high expression β3-adrenoceptors include urinary bladder, gall other parts gastrointestinal tract. While several have been proposed based on results obtained animals, their relevance humans remains uncertain. For instance, perform an important role thermogenesis lipolysis rodent brown white adipose tissue, respectively, but appears less significant. Moreover, use such as agonist BRL 37344 antagonist SR59230A demonstrate functional involvement may lead many cases misleading conclusions they can also interact β-adrenoceptor subtypes or even non-adrenoceptor targets. In conclusion, we propose that responses attributed stimulation need re-evaluation light development more selective tools. findings animals be extended order better understand potential additional indications side effects are beginning enter clinical medicine.