The relative systemic availability of ivermectin after administration as capsule, tablet, and oral solution.
作者： G. Edwards , A. Dingsdale , N. Helsby , M. L' E. Orme , A. M. Breckenridge
DOI: 10.1007/BF00637608
关键词:
摘要: Administration of 12-mg doses ivermectin (H2B1a) to 12 healthy volunteers in the form tablets, capsules, and alcoholic oral solution showed have approximately twice systemic availability as either solid forms, evidenced both by maximum concentrations drug attained plasma corresponding areas under concentration vs time curves. However, two formulations similar availability.
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Bruce M. Greene, Hugh R. Taylor, Eddie W. Cupp, Robert P. Murphy, Albert T. White, Mohammed A. Aziz, Hartwig Schulz-Key, Salvatore A. D'Anna, Henry S. Newland, Leonard P. Goldschmidt, Cheryl Auer, Aloysius P. Hanson, S. Vaanii Freeman, Earl W. Reber, P. Noel Williams, Comparison of Ivermectin and Diethylcarbamazine in the Treatment of Onchocerciasis New England Journal of Medicine. ,vol. 313, pp. 133- 138 ,(1985) , 10.1056/NEJM198507183130301
R. Chiou, R.J. Stubbs, W.F. Bayne, Determination of ivermectin in human plasma and milk by high-performance liquid chromatography with fluorescence detection. Journal of Chromatography B: Biomedical Sciences and Applications. ,vol. 416, pp. 196- 202 ,(1987) , 10.1016/0378-4347(87)80502-9
Paul K. Wilkinson, David G. Pope, Francis P. Baylis, Pharmacokinetics of ivermectin administered intravenously to cattle. Journal of Pharmaceutical Sciences. ,vol. 74, pp. 1105- 1107 ,(1985) , 10.1002/JPS.2600741020
A. T. White, H. S. Newland, H. R. Taylor, K. D. Erttmann, E. K. Larijani, A. Nara, M. A. Aziz, S. A. D'Anna, P. N. Williams, B. M. Greene, Controlled Trial and Dose-Finding Study of Ivermectin for Treatment of Onchocerciasis The Journal of Infectious Diseases. ,vol. 156, pp. 463- 470 ,(1987) , 10.1093/INFDIS/156.3.463
K. Awadzi, K. Y. Dadzie, H. Shulz-Key, D. R. W. Haddock, H. M. Gilles, M. A. Aziz, The chemotherapy of onchocerciasis X. An assessment of four single dose treatment regimes of MK-933 (ivermectin) in human onchocerciasis. Annals of Tropical Medicine and Parasitology. ,vol. 79, pp. 63- 78 ,(1985) , 10.1080/00034983.1985.11811889