Deconstruction of vulnerability to complex diseases: enhanced effect sizes and power of intermediate phenotypes.
作者： David Goldman , Francesca Ducci
DOI: 10.1100/TSW.2007.210
关键词:
摘要: The deconstruction of vulnerability to complex disease with the help intermediate phenotypes, including heritable and disease-associated endophenotypes, is a legacy Henri Begleiter. Systematic searches for genes influencing disorders, bipolar disorder, have recently been completed using whole genome association (WGA), identifying series validated loci. Using this information, it possible compare effect sizes loci discovered in very large samples replicated functional determining phenotypes that are essential interest psychiatric disorders. It shown tend larger size. Furthermore, WGA results reveal number size diseases limited, yet multiple already identified relevant diseases, without benefit WGA.
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