Family Study of Early-Onset Dysthymia

作者: Daniel N. Klein

DOI: 10.1001/ARCHPSYC.1995.03950180073010

关键词:

摘要: Background: The nosological status of dysthymia has generated considerable controversy. major issues include whether should be classified as a form mood or personality disorder and, if is disorder, it sufficiently distinct from depression to warrant separate category. Methods: We conducted family study 97 outpatients with early-onset dysthymia, 45 episodic depression, and normal controls, their 882 first-degree relatives. Axis I II disorders were assessed in relatives using direct informant interviews all available medical records. Results: rate the dysthymic probands was significantly greater than controls non-significantly depressive probands. both controls. Rates most increased compared In addition, had higher rates any cluster B those probands, although these differences disappeared after controlling for comorbidity Finally, without lifetime history did not differ on psychiatric Conclusions: There strong familial relationship between depression. However, also somewhat that aggregates specifically families patients dysthymia. appear have association disorders, link appears stronger

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