Cholic acid, chenodeoxycholic acid, alpha-1-fetoprotein and alpha-1-antitrypsin serum concentrations in breast-fed infants with prolonged jaundice.

摘要: Thirteen breast-fed one-month-old infants with prolonged jaundice not due to known causes were included in this study. All investigated at one and twelve months of age. Serum concentrations total (TB) conjugated bilirubin (CB), aspartate (ASAT) alanine aminotransferase (ALAT), alkaline phosphatase (AP), α-1-antitrypsin (α-1-AT), α-1-fetoprotein (AFP) the two primary bile acids; cholic (CA) chenodeoxycholic acid (CDCA) determined both ages. The Pi-phenotype α-1-AT was age months. serum TB, CB, AP AFP elevated month but normal No changes ASAT or ALAT observed between age, values within reference ranges. range Two heterozygous for MZ, they had concentrations. CA CDCA still significantly indicating that slight cholestasis month, largely subsided by end first year life.