Phosphorylation of IRS proteins Yin-Yang regulation of insulin signaling.

摘要: Growing evidence reveals that insulin signal pathway is not static, but rather a dynamic, flexible, and fed in by negative (Yin) positive (Yang) regulation response to environmental changes. Normal reflects the balance between Yin Yang acting upon signaling pathway. Conceivably, imbalance results abnormal sensitivity such as resistance. IRS-proteins are receptor substrates mediate via multiple tyrosyl phosphorylations. However, they also for many serine/threonine kinases downstream of other network become serine phosphorylated various conditions inflammation, stress over nutrients. The phosphorylation alters capacities be on tyrosyl, therefore, able signaling. unique structure render them idea molecules fulfill task sense cues integrate into through phosphorylation. This review intends summarize role with focuses Understanding dynamic these complicated net work only provide us complete picture what happens normal conditions, pathaphysiological obesity