Advances in therapeutic options for portal hypertension.
作者： Marina Vilaseca , Sergi Guixé-Muntet , Anabel Fernández-Iglesias , Jordi Gracia-Sancho
关键词:
摘要: Portal hypertension represents one of the major clinical consequences chronic liver disease, having a deep impact on patients' prognosis and survival. Its pathophysiology defines pathological increase in intrahepatic vascular resistance as primary factor its development, being subsequently aggravated by paradoxical portal blood inflow. Although extensive preclinical research field has been developed recent decades, no effective treatment targeting mechanism defined. The present review critically summarizes current knowledge therapeutics, focusing those strategies driven disease underlying cellular mechanisms.
sagepub.com
sci-hub.se 参考文章(158)
Yoshifumi Saisho, Metformin and Inflammation: Its Potential Beyond Glucose-lowering Effect. Endocrine‚ Metabolic & Immune Disorders-Drug Targets. ,vol. 15, pp. 196- 205 ,(2015) , 10.2174/1871530315666150316124019
Hayes P Ginès P, Angeli P, Lenz K, Møller S, Moore K, Moreau R, Merkel C, Ring-Larsen H, Bernardi M, Garcia-Tsao G, EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis. Journal of Hepatology. ,(2010) , 10.1016/J.JHEP.2010.05.004
Jieun Jung, Jong Ho Choi, Youjin Lee, Jong-Wan Park, Il-Hoan Oh, Seong-Gyu Hwang, Kwang-Soo Kim, Gi Jin Kim, Human Placenta‐Derived Mesenchymal Stem Cells Promote Hepatic Regeneration in CCl4‐Injured Rat Liver Model via Increased Autophagic Mechanism Stem Cells. ,vol. 31, pp. 1584- 1596 ,(2013) , 10.1002/STEM.1396
Tian-Yu Zhao, Li-Ping Su, Chun-Ye Ma, Xiao-Han Zhai, Zhi-Jun Duan, Ying Zhu, Gang Zhao, Chun-Yan Li, Li-Xia Wang, Dong Yang, IGF-1 decreases portal vein endotoxin via regulating intestinal tight junctions and plays a role in attenuating portal hypertension of cirrhotic rats BMC Gastroenterology. ,vol. 15, pp. 77- 77 ,(2015) , 10.1186/S12876-015-0311-5
Enric Reverter, Francisco Mesonero, Susana Seijo, Javier Martínez, Juan G Abraldes, Beatriz Peñas, Annalisa Berzigotti, Ramon Deulofeu, Jaume Bosch, Agustín Albillos, Joan Carles García-Pagán, Effects of Sapropterin on Portal and Systemic Hemodynamics in Patients With Cirrhosis and Portal Hypertension: A Bicentric Double-Blind Placebo-Controlled Study. The American Journal of Gastroenterology. ,vol. 110, pp. 985- 992 ,(2015) , 10.1038/AJG.2015.185
Erwin Biecker, Jonel Trebicka, Alice Kang, Martin Hennenberg, Tilman Sauerbruch, Jörg Heller, Treatment of bile duct-ligated rats with the nitric oxide synthase transcription enhancer AVE 9488 ameliorates portal hypertension. Liver International. ,vol. 28, pp. 331- 338 ,(2008) , 10.1111/J.1478-3231.2008.01664.X
Takeshi Fukuda, Yoshiyuki Narahara, Hidenori Kanazawa, Yoko Matsushita, Hideko Kidokoro, Norio Itokawa, Chisa Kondo, Masanori Atsukawa, Katsuhisa Nakatsuka, Choitsu Sakamoto, Effects of fasudil on the portal and systemic hemodynamics of patients with cirrhosis. Journal of Gastroenterology and Hepatology. ,vol. 29, pp. 325- 329 ,(2014) , 10.1111/JGH.12360
Xuguang Zhai, Kunfeng Yan, Jiye Fan, Minghui Niu, Qian Zhou, Yan Zhou, Hongshan Chen, Yajun Zhou, The β‐catenin pathway contributes to the effects of leptin on SREBP‐1c expression in rat hepatic stellate cells and liver fibrosis British Journal of Pharmacology. ,vol. 169, pp. 197- 212 ,(2013) , 10.1111/BPH.12114
Amanda J. Stolarz, Ryan A. Farris, Charla A. Wiley, Catherine E. O'Brien, Elvin T. Price, Fenofibrate Attenuates Neutrophilic Inflammation in Airway Epithelia: Potential Drug Repurposing for Cystic Fibrosis Clinical and Translational Science. ,vol. 8, pp. 696- 701 ,(2015) , 10.1111/CTS.12310
Arpan Mohanty, Janet P. Tate, Guadalupe Garcia-Tsao, Statins Are Associated With a Decreased Risk of Decompensation and Death in Veterans With Hepatitis C-Related Compensated Cirrhosis. Gastroenterology. ,vol. 150, pp. 430- 440 ,(2016) , 10.1053/J.GASTRO.2015.10.007