HAS THE 18-MONTH OUTCOME FOR EXTREMELY LOW GESTATIONAL AGE (ELGA) INFANTS OF 23-25 WEEKS GESTATION IMPROVED? † 1614

摘要: Our purpose was to examine the neurodevelopmental outcome at 18 months corrected age of surviving ELGA infants 23-25 weeks gestation born in 1991-3, and compare results with those from an earlier cohort 1983-9 (Synnes A et al J Pediatr 1994:125:952-60). delivered British Columbia's tertiary perinatal center had their gestational (GA) ascertained as accurately possible by early ultrasound dates using predetermined criteria. There were no survivors <23 two time periods. The multidisciplinary assessments performed a reviewed for GA. Major impairment defined Bayley MDI below -2 s.d., definite signs cerebral palsy (CP), visual acuity better eye optimal refractive correction worse than 20/200, or sensorineural hearing loss requiring amplification. Of 111 live births, 48 survived follow-up data available 35 (73%). 4 12 major impairment, multiple impairments. recent smaller size(3-year vs 7-year period) rate lower (73% 93%), sampling bias toward birthweight infants. Survival (to discharge) GA has not improved (44% 44%) comparable incidence (34%; 36% resp.). children impairments, impairments present 33% (vs 38% cohort). As there so few 23 week babies, re-analyzed 24-25 (53% 50%) (32% 34%) remained statistically different. is evidence this survey that introduction innovations such surfactant therapy produced any improvement outcomes smallest babies.Table