Melanoma inhibitory activity promotes melanoma development through activation of YBX1
作者： Rainer Schmid , Katharina Meyer , Rainer Spang , Birgit Schittek , Anja-Katrin Bosserhoff
DOI: 10.1111/PCMR.12119
关键词:
摘要: Melanoma inhibitory activity (MIA), a small soluble secreted protein, is functionally important for progression of malignant melanoma. We recently revealed that p54(nrb) acts as mediator MIA action. In this study, we characterize the transcriptional regulation by to explain MIA's molecular identified one highly conserved region in promoter necessary and sufficient MIA-dependent activation. Functional analysis transcription factor YBX1 activation transcription. screened genome further potential MIA-regulated genes carrying element their regions. Integrating our sequence data with expression from human melanomas list 23 MIA-YBX1 targets melanomas. summary, present first time effects on regulation. Uncovering new downstream effectors working via supports role
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