From Mice to Men: research models of developmental programming.

摘要: Developmental programming can be defined as a response to specific challenge the mammalian organism during critical developmental time window that alters trajectory of development with persistent effects on offspring phenotype and predisposition future illness. We focus need for studies in relevant, well-characterized animal models context recent research discoveries challenges, mechanisms outcomes programming. discuss commonalities differences general principles they apply several species, including humans. The consequences these are discussed. Obesity, metabolic disorders cardiovascular diseases associated highest percentage morbidity mortality worldwide. Although many causes lifestyle, high-energy diets lack physical activity, evidence has linked epidemic diseases. A better understanding comparative systems physiology mother, fetus neonate using information provided by rapid advances molecular biology potential improve lifetime health generations providing women's health, diagnostic tools preventative therapeutic interventions individuals exposed their influences.