Pharmacodynamics of IV Citalopram Using Functional MRI

摘要: Although much is known about the role of serotonin (5-HT) in pathophysiology depression, little temporal and regional brain alterations 5-HT as they relate to treatment depression anxiety. This study aimed evaluate acute effects selective reuptake inhibitor (SSRI), citalopram, on neuronal activation elicited during an emotional task using functional MRI (fMRI) healthy subjects. Eight men completed double-blind placebo-controlled crossover citalopram (20 mg infused over 30 min) normal saline. Subjects performed once before drug/placebo infusion (Faces 1) twice infusion, early 2) at end 3). A main effect was found L R amygdala. cluster right amygdala had increased for Faces 2 compared baseline 1 task. An even greater bilateral response 3), when concentrations approach their maxima, suggests that administration potentiates stimuli. exploratory analysis done transporter genotype a covariate. S allele carriers (2 s/s 3 s/l) than l/l (n=3) homozygotes. However homozygotes comparing generated first vivo human data regarding intravenous SSRI affective task-related activation. understanding SSRIs may aid mechanism by which these agents produce therapeutic effects. By including 5-HTTLPR analyses, we account some variability other SSRIs. These efforts contribute identification biological mechanisms pathways mediate SSRIs, our individual differences complex behaviors vulnerability psychiatric illnesses.