Vitamin D–deficiency rickets among children in Canada

摘要: Background: Based on regional and anecdotal reports, there is concern that vitamin D–deficiency rickets persistent in Canada despite guidelines for its prevention. We sought to determine the incidence clinical characteristics of among children living Canada. Methods: A total 2325 Canadian pediatricians were surveyed monthly from July 1, 2002, June 30, 2004, through Paediatric Surveillance Program incidence, geographic distribution profiles confirmed cases D-deficiency rickets. calculated rates based number over product length study period (2 years) estimates population by age group. Results: There 104 D– deficiency during period. The overall annual rate was 2.9 per 100 000. highest residing north (Yukon Territory, Northwest Territories Nunavut). mean at diagnosis 1.4 years (standard deviation [SD] 0.9, min–max 2 weeks–6.3 years). Sixty-eight (65%) had lived urban areas most their lives, 57 (55%) identified Ontario. Ninety-two (89%) intermediate or darker skin. Ninety-eight (94%) been breast-fed, 3 (2.9%) fed standard infant formula. None breast-fed infants received D supplementation according current (400 IU/d). Maternal risk factors included limited sun exposure a lack diet supplements pregnancy lactation. majority showed clinically important morbidity diagnosis, including hypocalcemic seizures (20 cases, 19%). Interpretation: Vitamin Canada, particularly who reside with skin are without appropriate supplementation. Since no reported having regular IU/d) birth developed rickets, prevention can be effective but not being consistently implemented. exception appears infants, those formula, born mothers profound deficiency, which case may adequate rescue D-deficient state.